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Related Experiment Video

Updated: Jan 13, 2026

Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
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Functional gradient alteration and structural remodeling in postpartum women.

Shiyu Xia1, Xinyu Zhao2, Bin Lv3

  • 1Department of Radiology, Medical Image Center, West China Second University Hospital, Sichuan University, Chengdu, China; Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu, China.

Neuroimage
|January 9, 2026
PubMed
Summary

Postpartum women show significant brain network changes, including reduced functional gradients and gray matter volume, impacting information processing and linked to sleep and anxiety symptoms.

Keywords:
Brain network topologyFunctional connectome gradientsGMVMaternal brain adaptationPostpartum women

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Area of Science:

  • Neuroscience
  • Brain Imaging
  • Neuroplasticity

Background:

  • Postpartum women (PW) experience significant brain reorganization for maternal adaptation.
  • The precise large-scale neural mechanisms underlying these adaptations remain largely unknown.

Purpose of the Study:

  • To investigate brain connectome reorganization in postpartum women using multimodal MRI.
  • To explore the relationship between neural changes and clinical symptoms.

Main Methods:

  • Multimodal MRI approach integrating functional gradient analysis, graph-theoretical network metrics, and morphometry.
  • Comparison between 134 postpartum women (PW) and 75 healthy nulliparous women (HNW).

Main Results:

  • PW exhibited contracted functional gradients, reduced network segregation, and less efficient information processing compared to HNW.
  • Gray matter volume (GMV) reductions were observed in PW, mediating functional gradient reorganization.
  • Neural changes correlated with clinical symptoms like poor sleep quality and anxiety.

Conclusions:

  • Postpartum brain undergoes large-scale network reconfiguration, indicating adaptive plasticity.
  • GMV alterations play a key role in modulating functional network changes during the postpartum period.