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Related Experiment Video

Updated: Jan 13, 2026

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

Decoding brain border immunity to enable future therapeutic avenues.

Lien Van Hoecke¹, Lore Van Acker¹, Roosmarijn E Vandenbroucke¹

¹VIB Center for Inflammation Research, VIB, Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.

Trends in Immunology

|January 9, 2026

Summary

The brain

Keywords:

blood–brain barrier choroid plexus meninges neuro-immunology neuroimmunotherapy skull bone marrow

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Last Updated: Jan 13, 2026

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

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Published on: April 9, 2019

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

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Precise Brain Mapping to Perform Repetitive In Vivo Imaging of Neuro-Immune Dynamics in Mice

Precise Brain Mapping to Perform Repetitive In Vivo Imaging of Neuro-Immune Dynamics in Mice

Published on: August 7, 2020

Area of Science:

Neuroimmunology
Central Nervous System (CNS) Immunity
Brain Border Immunology

Background:

The brain was historically considered immunologically isolated.
Emerging research highlights dynamic border compartments coordinating brain-periphery communication.
Key interfaces include meninges, blood-brain barrier, choroid plexus, and skull bone marrow.

Purpose of the Study:

To explore the immune roles of the brain's border compartments.
To understand how these interfaces regulate central nervous system (CNS) immunity.
To identify therapeutic targets at the brain's periphery.

Main Methods:

Advanced imaging techniques.
Single-cell profiling.
Spatial profiling.

Main Results:

Discovery of novel cell types and migration routes.
Characterization of specialized immune niches at brain interfaces.
Elucidation of barrier specializations influencing CNS immunity.

Conclusions:

Brain border tissues are critical for immune surveillance and neuroimmune signaling.
Understanding these interfaces offers therapeutic potential for CNS disorders.
Targeting brain periphery can modulate neuroimmune responses while preserving brain function.