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Updated: Jan 13, 2026

Animal Model of Implant-Associated Infections in Mice
Published on: June 27, 2025
Emerging non-antibiotic strategies for implant-associated biofilm infections by reprogramming the dysregulated immune
Yu Zhang1, Zhuo Dai1, Xiaoye Li1
1Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, Jiangsu, China.
Abstract:
Implant-associated infections (IAIs) arise from immune dysregulation and the resilience of bacterial biofilms, which create a permissive niche for persistent infection. Biofilms further suppress host immunity and impair repair. Advances in nanoengineered surfaces and multifunctional antimicrobial coatings, together with gas-releasing and stimulus-responsive nanoplatforms, offer effective non-antibiotic strategies to inhibit colonization, disrupt biofilms, and modulate local immunity. This review summarizes emerging immune-informed approaches for treating IAIs.
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