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An infant with chronic relapsing urticaria

Candice N Gard1, Jennifer Blase2, Aimee Speck1

  • 1From the Division of Allergy and Clinical Immunology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan and.

Allergy and Asthma Proceedings
|January 9, 2026
PubMed

Insights

A persistent rash in infants, chronic urticaria, often lacks a clear cause. This case study emphasizes thorough evaluation for young children with difficult-to-treat hives.

Area of Science:

  • Pediatrics
  • Immunology
  • Dermatology

Background:

  • Chronic urticaria in children has diverse potential causes including infections, physical factors, autoimmune, and autoinflammatory conditions.
  • Identifying the specific etiology of chronic urticaria is frequently challenging.
  • Urticaria in infants presents unique diagnostic considerations.

Purpose of the Study:

  • To investigate the potential causes of persistent chronic urticaria in a 5-month-old infant.
  • To highlight the importance of a detailed history and comprehensive evaluation in pediatric chronic urticaria cases.
  • To discuss diagnostic approaches for recalcitrant urticaria in early childhood.

Main Methods:

  • Case report of a 7-month-old female infant with chronic urticaria.
  • Documentation of clinical presentation, including age of onset and duration.
  • Assessment of response to standard antihistamine therapy (H1 and H2 blockade).

Main Results:

  • The infant presented with persistent urticaria starting at 5 months of age.
  • The urticaria showed a poor response to both H1 and H2 blockade.
  • The case underscores the need for further investigation beyond initial treatments.

Conclusions:

  • Chronic urticaria in infants may require a broader diagnostic workup.
  • Thorough patient history and consideration of age-specific factors are crucial.
  • Identifying the underlying cause of pediatric chronic urticaria is essential for effective management.

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