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Related Experiment Video

Updated: Jan 13, 2026

Basophil Activation Test for Allergy Diagnosis

Basophil Activation Test for Allergy Diagnosis

Published on: May 31, 2021

An infant with chronic relapsing urticaria.

Candice N Gard¹, Jennifer Blase², Aimee Speck¹

¹From the Division of Allergy and Clinical Immunology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan and.

Allergy and Asthma Proceedings

|January 9, 2026

Summary

A persistent rash in infants, chronic urticaria, often lacks a clear cause. This case study emphasizes thorough evaluation for young children with difficult-to-treat hives.

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Area of Science:

Pediatrics
Immunology
Dermatology

Background:

Chronic urticaria in children has diverse potential causes including infections, physical factors, autoimmune, and autoinflammatory conditions.
Identifying the specific etiology of chronic urticaria is frequently challenging.
Urticaria in infants presents unique diagnostic considerations.

Purpose of the Study:

To investigate the potential causes of persistent chronic urticaria in a 5-month-old infant.
To highlight the importance of a detailed history and comprehensive evaluation in pediatric chronic urticaria cases.
To discuss diagnostic approaches for recalcitrant urticaria in early childhood.

Main Methods:

Case report of a 7-month-old female infant with chronic urticaria.
Documentation of clinical presentation, including age of onset and duration.
Assessment of response to standard antihistamine therapy (H1 and H2 blockade).

Main Results:

The infant presented with persistent urticaria starting at 5 months of age.
The urticaria showed a poor response to both H1 and H2 blockade.
The case underscores the need for further investigation beyond initial treatments.

Conclusions:

Chronic urticaria in infants may require a broader diagnostic workup.
Thorough patient history and consideration of age-specific factors are crucial.
Identifying the underlying cause of pediatric chronic urticaria is essential for effective management.