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A prospective, triple-blind, randomized controlled clinical trial evaluating the protective effect of P11-4 peptide

Anahita Jablonski-Momeni1, Teresa Temming2, Jan-Niklas Berthold2

  • 1Dental School, Department of Orthodontics, Philipps-Universität Marburg, Georg-Voigt Str. 3, Marburg, 35039, Germany. momeni@staff.uni-marburg.de.

BMC Oral Health
|January 9, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Caries preventionEnamel demineralizationFluorideMultibracket appliancesOrthodonticsP11-4 peptideQLF

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Blinding01:11

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.