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Cellular Senescence as a Risk Factor in Head and Neck Cancer-Diagnostic and Therapeutic Perspective
Magdalena Stachowiak1,2,3, Magdalena Kostrzewa2, Wojciech Golusinski1
1Department of Head and Neck Surgery, Poznan University of Medical Sciences, 61-701 Poznan, Poland.
Cancers
|January 10, 2026
Summary
Cellular senescence, a process linked to aging, may play a role in head and neck cancer (HNC) development. This review explores the connection between senescence and HNC, impacting prognosis, prevention, and therapy.
Area of Science:
- Oncology
- Cell Biology
Background:
- Head and neck cancer (HNC) impacts nearly 1 million individuals annually.
- Key risk factors include tobacco, alcohol, and human papilloma virus (HPV) infections.
- The precise mechanisms driving HNC development are not fully understood.
Purpose of the Study:
- To review the current understanding of cellular senescence in relation to head and neck cancer.
- To explore the role of senescence in HNC carcinogenesis, prognosis, prevention, and therapy.
Main Methods:
- Literature review of studies investigating cellular senescence and HNC.
- Analysis of the biological mechanisms linking senescence to cancer development.
Main Results:
- Cellular senescence is an aging-associated process involving growth arrest and altered cellular functions.
- Senescence may influence cell metabolism and secretory phenotype, potentially impacting carcinogenesis.
- The specific role and mechanisms of senescence in HNC require further elucidation.
Conclusions:
- Cellular senescence is a potential factor in head and neck cancer development.
- Understanding senescence could offer new avenues for HNC prognosis, prevention, and treatment.
- Further research is needed to fully clarify the association between senescence and HNC.
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