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Metastatic Uveal Melanoma Surveillance: A Delphi Panel Consensus
Juan Alban1, R Christopher Bowen2, David A Reichstein3
1Robert H. Lurie Comprehensive Cancer Center, Division of Hematology Oncology, Northwestern University, Chicago, IL 60616, USA.
Cancers
|January 10, 2026
Summary
This study developed expert consensus recommendations for uveal melanoma surveillance, incorporating gene expression profiling (GEP) and PRAME status. The guidance aims to standardize post-treatment monitoring for this rare cancer.
Area of Science:
- Ophthalmology
- Oncology
- Medical Imaging
Background:
- Uveal melanoma is an aggressive eye cancer with high metastasis rates, often to the liver.
- Current post-treatment surveillance lacks standardized guidelines, leading to practice variations.
- Effective surveillance is crucial for early detection of metastasis.
Purpose of the Study:
- To establish expert consensus recommendations for uveal melanoma surveillance strategies.
- To develop a standardized framework for post-treatment monitoring.
- To incorporate molecular prognostic factors into surveillance guidelines.
Main Methods:
- A modified Delphi method was employed over three survey rounds (September 2024 - February 2025).
- A multidisciplinary panel of 41 North American experts participated.
- Consensus required ≥70% agreement on statements regarding risk-based surveillance, including gene expression profiling (GEP) and PRAME status.
Main Results:
- Twelve statements achieved stable consensus on imaging modality, frequency, and duration for intermediate- and high-risk patients.
- Experts agreed on the need for surveillance in low-risk patients, but no consensus on the optimal approach was reached.
- The study involved 41 experts from diverse oncological specialties across North America.
Conclusions:
- This study provides the first consensus-based guidance for uveal melanoma surveillance incorporating GEP and PRAME status.
- The recommendations offer a standardized framework to guide clinical practice and future research.
- Standardized surveillance may improve outcomes for patients with uveal melanoma.
