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Updated: Jan 13, 2026

Quantification of Humic and Fulvic Acids in Humate Ores, DOC, Humified Materials and Humic Substance-Containing Commercial Products
Published on: March 18, 2022
Pharmacological Effects of Humic Substances and Their Signaling Mechanisms
Maria V Zykova1, Evgenia S Trofimova1,2, Lyudmila A Azarkina1
1Faculty of Pharmacy, Siberian State Medical University, Tomsk 634050, Russia.
Humic substances exhibit diverse biological activities, offering potential pharmacological applications for various diseases. Their natural origin, broad efficacy, and safety profile drive significant scientific interest.
Area of Science:
- Biochemistry
- Pharmacology
- Toxicology
Background:
- Humic substances possess a unique chemical structure enabling diverse applications, including medicine.
- Modern pharmaceutical, pharmacological, and toxicological advancements reveal their multifaceted biological activity.
Purpose of the Study:
- To conduct an in-depth literature review on the biological activity and pharmacological mechanisms of humic substances.
- To explore their therapeutic potential for infectious and non-infectious diseases.
Main Methods:
- Analytical literature search.
- Review of data on biological effects, safety, and nanobiomaterial applications.
Main Results:
- Humic substances demonstrate immunotropic, antibacterial, antiviral (including HIV), antitumor, antioxidant, cardiotropic, hepatoprotective, regenerative, detoxifying, and adaptogenic effects.
- They positively influence the intestinal microbiome and show potential in creating next-generation bionanomaterials.
- Studies confirm their safety and lack of toxic/allergenic properties.
Conclusions:
- The natural origin, broad biological activity, and safety of humic substances support their growing scientific interest.
- They hold promise for treating and preventing a wide range of pathologies, including currently incurable diseases.
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