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Ultralong Hydroxyapatite Nanowires: Promising Flexible Building Blocks for Constructing High-Performance Biomimetic
Han-Ping Yu1, Ying-Jie Zhu1,2
1Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China.
Molecules (Basel, Switzerland)
|January 10, 2026
Summary
Flexible ultralong hydroxyapatite nanowires offer a solution to brittle traditional materials. These novel nanowires enable the creation of high-performance biomimetic materials with enhanced properties and diverse applications.
Area of Science:
- Materials Science
- Biomimetics
- Nanotechnology
Background:
- Traditional hydroxyapatite materials are stiff and brittle, limiting their use.
- Nature utilizes hierarchical structures from nanoscale building blocks for high-performance materials.
- Engineering flexible nanofibers from natural principles is a key challenge.
Purpose of the Study:
- To review advances in flexible ultralong hydroxyapatite nanowires and their biomimetic applications.
- To discuss synthetic methods, assembly strategies, properties, and applications.
- To highlight design principles and future research directions.
Main Methods:
- Synthesis of flexible ultralong hydroxyapatite nanowires via a calcium oleate precursor solvothermal method.
- Assembly of nanowires into hierarchical biomimetic structures inspired by natural materials (enamel, nacre, bone).
- Characterization of mechanical properties (strength, toughness, flexibility) and multifunctional capabilities (thermal insulation, biomedical compatibility).
Main Results:
- Successful synthesis of flexible ultralong hydroxyapatite nanowires.
- Demonstrated assembly into biomimetic structures with enhanced mechanical properties.
- Exploration of applications in various fields, showcasing versatility.
Conclusions:
- Flexible ultralong hydroxyapatite nanowires are versatile building blocks for advanced biomimetic materials.
- Biomimetic design principles can be distilled to engineer high-performance materials.
- This field holds significant promise for future applications and research.

