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Poly(levodopa)-Modified β-(1 → 3)-D-Glucan Hydrogel Enriched with Triangle-Shaped Nanoparticles as a Biosafe Matrix
Anna Michalicha1, Vladyslav Vivcharenko2, Anna Tomaszewska3
1Chair and Department of Biochemistry and Biotechnology, Medical University of Lublin, Chodzki 1, 20-093 Lublin, Poland.
Molecules (Basel, Switzerland)
|January 10, 2026
Summary
This study developed novel antibacterial wound dressings using modified curdlan hydrogels with silver nanoparticles and poly(L-DOPA). These biocompatible dressings show excellent antibacterial activity and promote wound healing properties.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Polymer Chemistry
Background:
- Natural-origin polymers in wound dressings often lack essential functionalities like antibacterial properties.
- Developing advanced wound dressings requires incorporating features for enhanced therapeutic outcomes.
Purpose of the Study:
- To fabricate biosafe, antibacterial wound dressings by modifying curdlan-based hydrogels.
- To integrate triangle-shaped silver nanoparticles (AgTNPs) and poly(L-DOPA) (PL) for improved functionality.
- To assess the physicochemical, structural, biological, and antibacterial properties of the developed hydrogels.
Main Methods:
- Fabrication of curdlan-based hydrogels modified with AgTNPs and PL.
- Comprehensive characterization including physicochemical, structural, and biological assessments.
- Evaluation of antibacterial efficacy against Staphylococcus aureus and Pseudomonas aeruginosa.
- Assessment of biocompatibility using eukaryotic cell models and a zebrafish larvae model.
- Analysis of blood clot formation and heat-generating capabilities.
Main Results:
- All hydrogel formulations were non-toxic to eukaryotic cells.
- Poly(L-DOPA) significantly reduced mortality in the zebrafish larvae model, indicating enhanced biocompatibility.
- The three-component hydrogel (CUR-PL-AgT) exhibited high antibacterial effectiveness against S. aureus and P. aeruginosa.
- The CUR-PL-AgT hydrogel promoted blood clot formation more effectively than hydrogels with AgTNPs alone.
- Poly(L-DOPA) enhanced the heat-generating capability of the hydrogels.
Conclusions:
- The developed curdlan-based hydrogels with AgTNPs and PL are biosafe and possess significant antibacterial properties.
- The incorporation of PL improves hydrogel biocompatibility and wound healing potential.
- These novel hydrogels demonstrate potential for advanced wound dressing applications due to their antibacterial, hemostatic, and thermogenic properties.
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