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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
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The Apelinergic System in Kidney Disease: Novel Perspectives
Sara Saladich-Cavallé1, Sara Núñez-Delgado1,2, Linhui Huo1
1Nephrology and Transplantation Research Group, Vall d'Hebrón Research Institute (VHIR), Vall d'Hebron University Hospital, Vall d'Hebron Barcelona Hospital Campus, 08035 Barcelona, Spain.
International Journal of Molecular Sciences
|January 10, 2026
Summary
The apelinergic system, involving apelin and APLNR, is crucial for kidney function in diabetes. Dysregulation of this system in diabetic kidney disease presents a promising therapeutic target for new treatments.
Area of Science:
- Nephrology
- Endocrinology
- Pharmacology
Background:
- Diabetic kidney disease (DKD) affects 30-40% of diabetes patients, often progressing to end-stage renal disease (ESRD).
- The apelin/APLNR system in renal vasculature is vital for glucose uptake and blood flow regulation.
- This system is known to be dysregulated in DKD.
Purpose of the Study:
- To review the role of the apelinergic system in diabetic kidney disease.
- To summarize current apelin analogs and inhibitors.
- To discuss their therapeutic potential for DKD.
Main Methods:
- Literature review of recent studies on apelin, APLNR, and DKD.
- Analysis of cellular mechanisms of apelin action.
- Examination of existing apelin-targeting therapeutics.
Main Results:
- The apelinergic system plays a significant role in DKD pathogenesis.
- Apelin analogs and inhibitors are under development.
- These agents show potential for treating DKD.
Conclusions:
- The apelinergic system is a key factor in DKD.
- Apelin-based therapies offer a promising avenue for DKD treatment.
- Further research into apelin analogs and inhibitors is warranted.
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