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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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RNA-Binding Proteins: Modulators of Canonical Wnt Signaling Pathway.

Michael S Czap1, Vikash Singh1, Vladimir S Spiegelman1

  • 1Division of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

International Journal of Molecular Sciences
|January 10, 2026
PubMed
Summary

RNA-binding proteins (RBPs) regulate gene expression and are key modulators of the Wnt signaling pathway. Their dysregulation is linked to diseases, highlighting their therapeutic potential in Wnt-driven conditions.

Keywords:
N6-Methyladenosine (m6A)RBP (RNA binding protein)RNA recognition motif (RRM)Wnt/β-cateninheterogenous nuclear K-homology (KH)untranslated region (UTR)

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Area of Science:

  • Molecular Biology
  • Cellular Signaling
  • Gene Regulation

Background:

  • RNA-binding proteins (RBPs) are crucial for post-transcriptional gene regulation.
  • The canonical Wnt signaling pathway controls cell fate, proliferation, and tumorigenesis.
  • RBPs are increasingly recognized as modulators of Wnt signaling.

Purpose of the Study:

  • To review the role of RBPs in regulating the canonical Wnt signaling pathway.
  • To highlight the molecular mechanisms and functional implications of RBP-Wnt interactions.
  • To explore RBPs as potential therapeutic targets in Wnt-driven diseases.

Main Methods:

  • Literature review of studies on RBPs and Wnt signaling.
  • Analysis of molecular mechanisms by which RBPs affect Wnt pathway components.
  • Discussion of the link between RBP dysregulation, Wnt signaling, and disease pathology.

Main Results:

  • RBPs control Wnt pathway component stability, localization, and translation.
  • Specific RBPs like IGF2BP1, HuR, and MSI1 directly regulate key Wnt factors.
  • Aberrant Wnt signaling due to RBP dysregulation contributes to cancers and developmental disorders.

Conclusions:

  • RBPs are critical regulators of canonical Wnt signaling.
  • Understanding RBP-Wnt interactions offers insights into cellular homeostasis and disease.
  • Targeting RBPs presents a promising therapeutic strategy for Wnt-related pathologies.