Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ribosome Profiling02:24

Ribosome Profiling

4.1K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
4.1K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.5K
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NeuroStat: An Open-Source EEG Connectivity Platform for Randomised Controlled Trials.

Sensors (Basel, Switzerland)·2026
Same author

Quality assessment of OSCE-style examinations in a chiropractic program: A follow-up report.

The Journal of chiropractic education·2026
Same author

Nonlinear EEG Complexity as a Marker of Maladaptive Brain Plasticity in Substance Use Disorders: A Multi-Group Machine Learning Classification Study.

Brain sciences·2026
Same author

Corrigendum to "Effect of midodrine on orthostatic intolerance after hip and knee arthroplasty: A randomized controlled trial (the MOBiLE study)" [Journal of Clinical Anesthesia, Volume 113 (2026), 112261].

Journal of clinical anesthesia·2026
Same author

Outcomes of Lobectomy Versus Sublobar Resection for Clinical Stage IA3 Non-Small Cell Lung Cancer.

The Annals of thoracic surgery·2026
Same author

Understanding the chemistry of re-emerging proton batteries.

Chemical Society reviews·2026

Related Experiment Video

Updated: Jan 13, 2026

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation
06:28

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation

Published on: December 13, 2024

1.1K

Unique RNA Gene Expression Profile Is Seen in Chronic Non-Specific Low Back Pain.

Ann-Christin Sannes1,2, Imran Amjad3,4, Jenna Duehr4,5

  • 1Faculty of Health Science, Oslo Metropolitan University, 0176 Oslo, Norway.

International Journal of Molecular Sciences
|January 10, 2026
PubMed
Summary

Chronic low back pain (LBP) shows distinct immune cell gene expression linked to inflammation and neuroplastic changes. Early RNA profiling may guide targeted therapies for non-specific LBP progression.

Keywords:
RNA sequencinginflammationlow back painsensitization

More Related Videos

Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain
05:10

Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain

Published on: August 30, 2022

3.4K
Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model
07:34

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model

Published on: August 11, 2023

1.1K

Related Experiment Videos

Last Updated: Jan 13, 2026

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation
06:28

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation

Published on: December 13, 2024

1.1K
Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain
05:10

Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain

Published on: August 30, 2022

3.4K
Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model
07:34

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model

Published on: August 11, 2023

1.1K

Area of Science:

  • Immunology
  • Neuroscience
  • Genomics

Background:

  • Non-specific low back pain (nsLBP) progression from subacute to chronic stages involves nervous and immune system alterations.
  • Understanding these systemic changes is crucial for developing effective treatments.

Purpose of the Study:

  • To characterize gene expression profiles of circulating immune cells during the transition from subacute to chronic nsLBP.
  • To identify molecular differences between healthy, subclinical, and chronic nsLBP states.

Main Methods:

  • RNA sequencing of peripheral blood mononuclear cells from healthy controls, subclinical nsLBP patients, and chronic nsLBP patients.
  • Differential gene expression analysis to identify unique molecular signatures.

Main Results:

  • Chronic nsLBP exhibited a distinct gene expression profile with 139 unique differentially expressed genes (DEGs) compared to subclinical and control groups.
  • Minimal overlap in DEGs between chronic and subclinical groups highlighted a significant inflammatory distinction.
  • Chronic nsLBP patients showed altered gene expression related to axon guidance, suggesting neuroplastic changes.

Conclusions:

  • Chronic nsLBP is associated with a unique inflammatory and neuroplastic molecular profile.
  • Early identification of nsLBP progression via RNA profiling could enable targeted therapies.
  • Therapeutic strategies may focus on neuroplasticity and inflammatory pathways for chronic nsLBP.