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Updated: Jan 13, 2026

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
Published on: November 1, 2019
New Insights into TFEB SUMOylation and Its Role in Lipid Metabolism and Cardiovascular Disease
Qingxiu Meng1, Chun Guang Li2, Xiaolong Chen3
1School of Physical Education, Taiyuan University of Science and Technology, Taiyuan 030024, China.
Abstract:
Transcription factor EB (TFEB) plays a crucial role in lipid metabolism and is indispensable for maintaining intracellular metabolic homeostasis. Its functionality relies significantly on its subcellular localization and transcriptional activity. Recent studies have revealed that SUMOylation regulates the subcellular localization and transcriptional activity of TFEB. Numerous studies indicate that mutations or dysfunctions of TFEB SUMOylation sites, as vital regulatory mechanisms, are closely associated with lipid metabolism in cardiovascular disease. Thus, in this review, we provide an overview of the current knowledge and recent advances in TFEB SUMOylation, with a particular focus on the mechanism of TFEB SUMOylation and its role in lipid metabolism, providing potential new strategies for developing novel therapeutic treatments for cardiovascular diseases.
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