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Related Experiment Video

Updated: Jan 13, 2026

Quantification of Atherosclerosis in Mice
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Quantification of Atherosclerosis in Mice

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Rodent Models for Atherosclerosis.

Linghong Zeng1, Jingshu Chi2, Meiqi Zhu1

  • 1Department of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China, Hengyang 421001, China.

International Journal of Molecular Sciences
|January 10, 2026
PubMed
Summary
This summary is machine-generated.

Choosing the right animal model is crucial for studying atherosclerosis. Rodents like mice, rats, and hamsters offer different advantages for understanding cardiovascular disease mechanisms and developing new treatments.

Keywords:
atherosclerosisdyslipidemiahigh-fat and cholesterol dietrodent model

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Area of Science:

  • Cardiovascular Research
  • Animal Models of Disease
  • Atherosclerosis Pathogenesis

Background:

  • Atherosclerosis, a major cause of cardiovascular disease, involves dyslipidemia, inflammation, and plaque development.
  • Animal models are essential for studying atherosclerosis pathogenesis and testing therapies.
  • Rodent models are cost-effective and reproducible but have species-specific lipid metabolism differences.

Purpose of the Study:

  • To systematically review rodent model selection for atherosclerosis research.
  • To analyze the influence of sex and age on atherosclerosis development in rodent models.
  • To compare the suitability of mice, rats, and hamsters for different stages of atherosclerosis research.

Main Methods:

  • Review of commonly used rodent strains: C57BL/6J mice, Sprague-Dawley rats, Wistar rats, and golden hamsters.
  • Focus on atherosclerosis-prone backgrounds (Apoe-/- or Ldlr-/-).
  • Consideration of diet, sex, age, and lipid metabolism (HDL, LDL, CETP) in model selection.

Main Results:

  • Male C57BL/6J mice on Apoe-/- or Ldlr-/- backgrounds are preferred for late-stage plaque stability studies due to hypercholesterolemia and survival.
  • Rats (SD, Wistar) show slower atherosclerosis progression, suitable for early disease mechanism studies.
  • Hamsters offer human-like lipid metabolism but have variability and limited lesion progression, impacting reproducibility.

Conclusions:

  • Rodent model selection for atherosclerosis research must consider species-specific lipid metabolism and disease progression characteristics.
  • Mice are suitable for advanced plaque studies, while rats and hamsters are better for early mechanisms and human-mimetic lipid studies.
  • Careful optimization considering sex, age, and genetic background is vital for translational relevance in atherosclerosis research.