RLRL Therapeutic Feasibility and Potential Mechanism on Myopia

Area of Science:

• Ophthalmology
• Biomedical Engineering
• Public Health

Background:

• Myopia is a significant global health issue, especially in East Asia, with unclear underlying biological mechanisms.
• Current strategies for myopia control have limitations, highlighting the need for novel therapeutic approaches.

Purpose of the Study:

• To review the clinical aspects, epidemiology, and global impact of myopia.
• To explore the pathogenesis of myopia and existing intervention strategies.
• To examine the mechanistic evidence and safety of repeated low-level red light (RLRL) therapy for myopia control.

Main Methods:

• Literature review focusing on myopia definition, epidemiology, pathogenesis, and interventions.
• Analysis of emerging mechanistic evidence for RLRL therapy, including its effects on cellular and tissue levels.
• Assessment of the safety and feasibility of RLRL therapy.

Main Results:

• RLRL therapy, a photobiomodulation technique, shows efficacy in controlling axial elongation and refractive error.
• Mechanistic evidence suggests RLRL activates mitochondrial cytochrome c oxidase (CCO), enhances retinal metabolism, and influences choroidal and scleral remodeling.
• RLRL therapy is a potentially safe and feasible non-invasive approach.

Conclusions:

• RLRL therapy presents a promising novel strategy for slowing myopia progression.
• Understanding the mechanisms of RLRL therapy, including its impact on ocular tissues, is crucial for its clinical application.
• Further research into RLRL therapy could lead to effective myopia management solutions.