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Updated: Jan 13, 2026

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract
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Candida albicans Extracellular Vesicles Upregulate Nrg1 Transcription Repressor to Inhibit Self-Hyphal Development

Yu Wei1, Yujie Zhou2, Bolei Li1

  • 1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu 610041, China.

International Journal of Molecular Sciences
|January 10, 2026
PubMed
Summary

High concentrations of Candida albicans extracellular vesicles (EVs) inhibit fungal hyphal growth by upregulating NRG1. These EVs also improved survival in a mouse model of candidemia, suggesting therapeutic potential.

Keywords:
Candida albicansNRG1extracellular vesicleshyphaevirulence

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