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Gel Microparticles Based on Polymeric Sulfonates: Synthesis and Prospects for Biomedical Applications.

Olga D Iakobson¹, Elena M Ivan'kova¹, Yuliya Nashchekina²

¹Branch of Petersburg Nuclear Physics Institute Named by B.P. Konstantinov of National Research Centre "Kurchatov Institute"-Institute of Macromolecular Compounds, 199004 Saint-Petersburg, Russia.

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|January 10, 2026

Summary

Sulfonate-containing gel microspheres show high potential for drug delivery, effectively encapsulating doxorubicin and fuchsine. These porous particles offer superior drug loading capacity compared to non-porous alternatives.

Keywords:

drug carriers microspheres polysulfonates reverse suspension polymerization

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Area of Science:

Polymer chemistry
Materials science
Nanotechnology

Background:

Polyelectrolyte microspheres with sulfonate groups are promising for controlled drug release.
Their structure allows for drug encapsulation and prolonged administration.

Purpose of the Study:

To evaluate sulfonate-containing gel microparticles as drug delivery systems.
To assess their controlled administration of doxorubicin and fuchsine.

Main Methods:

Free-radical reverse suspension polymerization was used to create porous microspheres.
Microsphere properties were tuned by altering sulfonate type, comonomers, co-solvents, and crosslinkers.
Drug loading efficiency was influenced by these modifications.

Main Results:

Gel microspheres exhibited a porous, gel-like structure with sulfonate groups throughout.
Doxorubicin sorption capacity reached 2.2 mmol/g, significantly higher than non-porous particles (0.4 mmol/g).
Loading capacity was over 60 times greater than literature values for similar systems.

Conclusions:

Sulfonate-containing gel microspheres are effective drug delivery vehicles.
Their porous structure and sulfonate groups enhance drug loading and controlled release.
These microspheres offer a significant advancement over non-porous particles for drug delivery applications.