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Related Experiment Video

Updated: Jan 13, 2026

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

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Evaluation Starch-Based Hemostatic Agents "BioSight" as Adhesion Prevention Barrier Tested in an Adhesion Model in

Yi-Xin Liu^1,2, Chen-Ying Su^1,2, Min-Hsuan Yen³

¹Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1, Sec. 3, Zhongxiao E. Rd., Taipei 10608, Taiwan.

|January 10, 2026

Summary

BioSight, a new starch-based agent, effectively prevents postoperative abdominal adhesions in rats, comparable to existing treatments. Its hydrogel formation and balanced biodegradation offer promising clinical potential for reducing surgical complications.

Keywords:

4DryField® PH BioSight adhesion prevention barrier adhesions

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Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease

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Published on: September 20, 2018

Area of Science:

Biomaterials Science
Surgical Innovation
Regenerative Medicine

Background:

Postoperative abdominal adhesions are a significant surgical complication, causing pain, obstruction, and infertility.
Current prevention strategies have limitations, necessitating novel solutions.
BioSight, a novel starch-based agent, is investigated for its anti-adhesion properties.

Purpose of the Study:

To evaluate the efficacy of BioSight in preventing abdominal adhesions in a rat model.
To compare BioSight's performance against a predicate device, 4DryField® PH.
To assess the histopathological and macroscopic outcomes of BioSight application.

Main Methods:

A rat intra-abdominal adhesion model was established using 90 Sprague-Dawley rats.
Rats were assigned to BioSight, 4DryField® PH, or control groups.
Macroscopic scoring and histopathological analysis were performed at 2, 4, and 12 weeks post-surgery.

Main Results:

BioSight demonstrated significant anti-adhesion efficacy, comparable to 4DryField® PH.
Consistently low macroscopic adhesion scores (≤0.4) were observed up to 12 weeks.
Histological analysis showed reduced adhesion thickness with BioSight, especially at early stages (251.3 µm vs. 323.2 µm at Week 2).

Conclusions:

BioSight effectively prevents peritoneal adhesions in a rat model.
Its rapid hydrogel formation and balanced biodegradation contribute to its anti-adhesion properties.
BioSight shows clinical potential as a plant-derived, bioresorbable surgical adjunct for adhesion prevention.