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Acquired Reactive Perforating Collagenosis-A Rare Entity Occurring Within Common Disorders: A Systematic Review and
Maria Alexandra Junghetu1,2, Cristina Violeta Tutunaru3, Simona Laura Ianoși3
1Department of Oncologic Dermatology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Journal of Clinical Medicine
|January 10, 2026
Summary
Acquired reactive perforating collagenosis (ARPC) is a rare skin condition often linked to systemic diseases. This review summarizes ARPC diagnosis, management, and highlights the need for clinical trials.
Area of Science:
- Dermatology
- Pathology
- Systemic Diseases
Background:
- Acquired reactive perforating collagenosis (ARPC) is a rare skin disorder.
- It commonly affects adults with comorbidities like diabetes, chronic kidney disease (CKD), cardiovascular issues, and cancers.
- Drug-induced and trauma-related cases are also documented.
Purpose of the Study:
- To systematically review current diagnostic and therapeutic strategies for ARPC.
- To provide updated insights into managing this rare condition.
- To report an associated case of ARPC with CKD.
Main Methods:
- Systematic literature review adhering to PRISMA 2020 guidelines.
- PubMed database search for open-access, primary human studies within the last 15 years.
- Inclusion of adult patients with histopathologically confirmed ARPC.
Main Results:
- Twenty-seven studies (case reports/series) were analyzed, with a mean patient age of 60.8 years.
- Most ARPC cases presented with comorbidities; drug-induced cases were also noted.
- Diagnostic clues include pruritic papules with central keratotic plugs, supported by dermoscopy, reflectance confocal microscopy, and mandatory histopathology showing transepidermal collagen elimination.
Conclusions:
- Diagnosis of ARPC necessitates a comprehensive workup for underlying systemic diseases, including malignancies.
- Current treatments encompass antihistamines, keratolytics, corticosteroids, retinoids, phototherapy, dupilumab, and allopurinol.
- Further clinical trials are required to establish optimal therapeutic protocols for ARPC.
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