Verification of Efficacy of Cognitive Function Test Using the Cognitive Impairment Screening Test

Area of Science:

• Neurology
• Gerontology
• Public Health

Background:

• Early detection of cognitive impairment is crucial for timely intervention.
• The Cognitive Impairment Screening Test (CIST) was developed for early-stage cognitive impairment detection.
• Clinical utility of CIST requires validation in real-world settings.

Purpose of the Study:

• To compare the diagnostic performance of CIST against the previous screening test (PST).
• To validate the clinical utility of CIST in a large-scale real-world setting.

Main Methods:

• Analysis of 7,492,613 individuals' screening data from the ANSYS database (2017-2023).
• Comparison of CIST and PST scores, stratified by age, sex, and education.
• Assessment of discriminative performance using receiver operating characteristic (ROC) curves.
• Equipercentile equating method for score conversion between CIST and PST.

Main Results:

• CIST identified a higher proportion of cognitively impaired individuals (12.68%) than PST (10.72%).
• CIST demonstrated superior predictive accuracy (AUC=0.790) compared to PST (AUC=0.776).
• Established score conversions: CIST 20=PST 24, CIST 15=PST 20, CIST 5=PST 10.

Conclusions:

• The Cognitive Impairment Screening Test (CIST) is a valid and effective tool for screening cognitive impairment.
• CIST exhibits greater predictive accuracy than the previous screening test (PST).
• Caution is advised for direct score conversion between CIST and PST due to potential discrepancies.