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Updated: Jan 13, 2026

Alternative Method of Removing Otoliths from Sturgeon
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Otolith Deterioration: Factors Affecting Microvascular and Structural Integrity.

Eun-Hyeok Choi1, Ji-Hyung Park2, Hanim Kwon3

  • 1Dizziness Center, Clinical Neuroscience Center, Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Korea.

Journal of Clinical Neurology (Seoul, Korea)
|January 10, 2026
PubMed
Summary

Otolith function declines with age and sex, but systemic factors like free thyroxine and HDL cholesterol also impact otolith health. Understanding these factors is key to addressing dizziness and vertigo. Keywords: otolith function, dizziness, vertigo, systemic factors.

Keywords:
agingmetabolismotolithic membranevestibular evoked myogenic potentials.vestibular system

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Area of Science:

  • Otolaryngology
  • Neuroscience
  • Gerontology

Background:

  • Otolith degeneration is linked to aging, but other contributing factors remain unclear.
  • Dizziness and vertigo are common symptoms often associated with impaired otolith function.
  • Identifying risk factors for otolith dysfunction is crucial for effective patient management.

Purpose of the Study:

  • To identify systemic risk factors associated with otolith function in patients experiencing dizziness and vertigo.
  • To investigate the relationship between otolith function and various demographic and biochemical parameters.

Main Methods:

  • Cross-sectional study of 624 patients with vestibular disorders.
  • Otolith function assessed via summated amplitudes of cervical and ocular vestibular evoked myogenic potentials (SA-cVEMPs and SA-oVEMPs).
  • Generalized linear models used to analyze associations between otolith function and risk factors.

Main Results:

  • SA-cVEMP was negatively associated with age, female sex, and free thyroxine, and positively with HDL cholesterol.
  • SA-oVEMP showed negative association with age and positive association with female sex.
  • Age and sex were significant predictors for both SA-cVEMP and SA-oVEMP.

Conclusions:

  • Systemic factors, including free thyroxine and HDL cholesterol, significantly influence otolith function beyond age and sex.
  • These findings suggest microvascular and structural changes contribute to otolith degeneration.
  • Understanding these systemic impacts offers new insights into vestibular disorders and otolith health.