Related Experiment Video
Updated: Jan 13, 2026
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
Exceedingly Hyper-Secreting Parathyroid Adenoma: A Literature Review and Case Series
Delaney E S Clark1, Arati Bendapudi1, Connor B Haines1
1John Sealy School of Medicine, University of Texas Medical Branch at Galveston, Galveston, Texas, USA.
Background:
Hypercalcemia is most commonly caused by hyperparathyroidism, which is often due to the presence of a parathyroid adenoma and more rarely, a parathyroid carcinoma. Distinguishing between the two can be challenging when serum calcium and parathyroid hormone (PTH) levels are severely elevated. Carcinomas classically present with markedly increased values and more severe clinical symptoms.
Methods:
Clinical data was obtained via retrospective chart review and literature review.
Results:
Three cases of female patients with symptomatic hypercalcemia from primary hyperparathyroidism with markedly elevated PTH levels (755-3547.4 pg/mL) underwent uncomplicated parathyroid adenoma excision with no histopathologic evidence of malignancy. Appropriate intraoperative reduction in PTH levels was observed, and all patients experienced normalization in calcium levels postoperatively. There is a notable deficit in available literature regarding similar cases.
Conclusions:
Given the rarity of parathyroid carcinoma, these exceptional cases and laboratory values serve as a valuable reminder for clinicians about the diverse presentations of adenomas.
More Related Videos
Related Concept Videos
00:59The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
01:27Adrenal Gland Disorders
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
01:17Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...