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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

185
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
185
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

201
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
201
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

239
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
239
Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

171
Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
171
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

193
Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
193
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

250
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
250

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Updated: Jan 13, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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The MedSupport Multilevel Intervention to Enhance Support for Pediatric Medication Adherence: Development and

Elizabeth G Bouchard1, Hital Patel1, Paula C Vincent1

  • 1Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

Pediatric Blood & Cancer
|January 10, 2026
PubMed
Summary
This summary is machine-generated.

MedSupport, an intervention for pediatric acute lymphoblastic leukemia (ALL) patients, showed high feasibility and acceptability among caregivers and healthcare providers in a pilot study. Further research is needed to confirm its efficacy in improving medication adherence.

Keywords:
adherencebehavioral studiesoutcomes researchpediatric oncologypsychosocial

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Area of Science:

  • Pediatric Oncology
  • Pharmacology
  • Health Services Research

Background:

  • Medication adherence is critical for pediatric acute lymphoblastic leukemia (ALL) treatment effectiveness.
  • Existing interventions often fail to address the complex barriers to adherence.
  • The MedSupport intervention was developed to target these root causes.

Purpose of the Study:

  • To evaluate the feasibility and acceptability of the MedSupport intervention.
  • To gather preliminary data for a future full-scale randomized controlled trial.
  • To assess the intervention's potential to improve home-based chemotherapy adherence.

Main Methods:

  • A pilot study was conducted at Roswell Park involving caregivers and healthcare providers of pediatric ALL patients on oral chemotherapy.
  • Feasibility was assessed by participation rates, completion of screening questionnaires, and intervention fidelity.
  • Acceptability was measured using standardized self-report scales for both caregivers and healthcare providers.

Main Results:

  • 100% of eligible caregivers and healthcare providers agreed to participate, demonstrating high demand.
  • All participating families completed adherence barrier screening, with all endorsing barriers.
  • Both caregivers and healthcare providers rated the MedSupport intervention as highly acceptable, appropriate, and feasible.
  • Objective measures confirmed the feasibility of capturing intervention fidelity and demonstrated engagement.

Conclusions:

  • The MedSupport intervention is a feasible, acceptable, low-cost, and scalable approach.
  • The pilot study provides a strong foundation for future research into MedSupport's efficacy.
  • Further investigation is warranted to determine MedSupport's effectiveness in enhancing medication adherence for pediatric ALL patients.