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The MedSupport Multilevel Intervention to Enhance Support for Pediatric Medication Adherence: Development and

Elizabeth G Bouchard1, Hital Patel1, Paula C Vincent1

  • 1Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

Pediatric Blood & Cancer
|January 10, 2026
PubMed

Insights

MedSupport, an intervention for pediatric acute lymphoblastic leukemia (ALL) patients, showed high feasibility and acceptability among caregivers and healthcare providers in a pilot study. Further research is needed to confirm its efficacy in improving medication adherence.

Area of Science:

  • Pediatric Oncology
  • Pharmacology
  • Health Services Research

Background:

  • Medication adherence is critical for pediatric acute lymphoblastic leukemia (ALL) treatment effectiveness.
  • Existing interventions often fail to address the complex barriers to adherence.
  • The MedSupport intervention was developed to target these root causes.

Purpose of the Study:

  • To evaluate the feasibility and acceptability of the MedSupport intervention.
  • To gather preliminary data for a future full-scale randomized controlled trial.
  • To assess the intervention's potential to improve home-based chemotherapy adherence.

Main Methods:

  • A pilot study was conducted at Roswell Park involving caregivers and healthcare providers of pediatric ALL patients on oral chemotherapy.
  • Feasibility was assessed by participation rates, completion of screening questionnaires, and intervention fidelity.
  • Acceptability was measured using standardized self-report scales for both caregivers and healthcare providers.

Main Results:

  • 100% of eligible caregivers and healthcare providers agreed to participate, demonstrating high demand.
  • All participating families completed adherence barrier screening, with all endorsing barriers.
  • Both caregivers and healthcare providers rated the MedSupport intervention as highly acceptable, appropriate, and feasible.
  • Objective measures confirmed the feasibility of capturing intervention fidelity and demonstrated engagement.

Conclusions:

  • The MedSupport intervention is a feasible, acceptable, low-cost, and scalable approach.
  • The pilot study provides a strong foundation for future research into MedSupport's efficacy.
  • Further investigation is warranted to determine MedSupport's effectiveness in enhancing medication adherence for pediatric ALL patients.
Abstract

Keywords:
adherencebehavioral studiesoutcomes researchpediatric oncologypsychosocial

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