Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

PCR - Polymerase Chain Reaction

PCR - Polymerase Chain Reaction

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Redox- and Photo-Responsive Fe<sup>3+/2+</sup>-Cross-Linked Carboxymethyl Cellulose Methacrylate Dissipative Gels: Synthesis and Applications.

ACS applied materials & interfaces·2026

Same author

Dictated cell adhesion and migration using microfluidic-controlled synthetic hydrogels exhibiting programmable viscoelasticities.

Journal of materials chemistry. B·2026

Same author

Photoactivated Signaling Networks using DNA-Based Synthetic Organelles as Biomimetic Protocells.

Angewandte Chemie (International ed. in English)·2026

Same author

Allosteric ligand-aptamer complexes orchestrate supramolecular or transient catalytic, transcription and fibrinogenesis processes.

Chemical science·2026

Same author

Synthetic dynamic transcription frameworks and their applications.

Nature chemistry·2026

Same author

Cell-Membrane-Anchored Synthetic Dynamic DNA Circuits for Signaling Transient Cell Migration.

Journal of the American Chemical Society·2025

Same journal

Design Principles for Negative Thermal Expansion in Two-Dimensional Materials.

Accounts of chemical research·2026

Same journal

Main Group Redox Catalysis: New Frontiers with Germanium and Tin.

Accounts of chemical research·2026

Same journal

Taming Irreversibility in sp<sup>2</sup>-Carbon-Conjugated COFs from Polycrystalline Powders to Single Crystals and Thin Films.

Accounts of chemical research·2026

Same journal

Electroactive Imidazolium Ionic Liquids in Organic Synthesis.

Accounts of chemical research·2026

Same journal

Calix[4]resorcinarene-Based Porous Organic Cages: Synthesis and Applications.

Accounts of chemical research·2026

Same journal

Light-Driven Dual Rotary Molecular Motors and Beyond.

Accounts of chemical research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 30, 2026

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

Programmable Aptamer-Controlled Fibrinogenesis Using Dynamic DNA Networks and Synthetic Transcription Machineries.

Jiantong Dong¹, Diva Froim², Itamar Willner²

¹State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Frontiers Science Center for New Organic Matter, Research Center for Analytical Science, College of Chemistry, Nankai University, Tianjin 300071, P. R. China.

Accounts of Chemical Research

|January 10, 2026

Summary

This summary is machine-generated.

Researchers developed dynamic DNA networks to precisely control blood clot formation. This novel approach uses antithrombin aptamers for temporal modulation of thrombin, offering new possibilities for hemostasis regulation.

More Related Videos

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

Related Experiment Videos

Last Updated: Jun 30, 2026

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Plasmid-derived DNA Strand Displacement Gates for Implementing Chemical Reaction Networks

Published on: November 25, 2015

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection

Published on: February 9, 2024

Area of Science:

Biochemistry
Molecular Biology
Biotechnology

Background:

Fibrinogenesis, the process of fibrin formation, is crucial for hemostasis and clot formation at vascular injury sites.
Thrombin is the key enzyme in fibrinogenesis, making its activity a significant medical target.
Precise temporal, dose-controlled, and transient regulation of thrombin activity remains a challenge in current therapies.

Purpose of the Study:

To introduce dynamic DNA networks, reaction circuits, and transcription machineries for temporal modulation of thrombin activity.
To demonstrate the use of antithrombin aptamers within these frameworks for precise control of fibrinogenesis.
To explore phototriggered and oscillatory control of blood coagulation.

Main Methods:

Utilized constitutional dynamic networks (CDNs) with thrombin-inhibitory aptamers for dynamic regulation of fibrinogenesis.
Developed dissipative DNA reaction circuits and dynamic transcription machineries for transient control.
Implemented phototriggering and RNA/DNA duplexes with RNase H for temporal activation and inhibition of thrombin.

Main Results:

Demonstrated orthogonal dynamic regulatory frameworks leading to upregulated or downregulated fibrinogenesis via phototriggered CDNs.
Achieved transient upregulation or downregulation of fibrinogenesis by coupling CDNs to transient reaction modules.
Successfully implemented transcription machineries for phototriggered transient and oscillatory inhibition of thrombin, enabling spatiotemporal control of fibrinogenesis.

Conclusions:

Dynamic DNA networks provide a versatile platform for precise temporal control of thrombin activity and fibrinogenesis.
Phototriggered and oscillatory systems offer advanced spatiotemporal regulation of blood coagulation.
These nucleic acid-based frameworks hold significant potential for future therapeutic strategies in hemostasis.