One-Pot Transition-Metal-Free Methods for the Synthesis of All Three Bonds of the Alkyne's Triple Bond

Alkynes are among the most useful functional groups in synthetic chemistry, as they are excellent starting materials for various reactions and serve as valuable precursors during total synthesis. Despite the high number of transformations that utilize alkynes as substrates, few methods actually exist to synthesize them. Known methods involve several synthetic steps, harsh conditions, or cryogenic temperatures, which render them inconvenient and inefficient. This review of alkyne syntheses cover methods that enable the formation of all three bonds of the alkyne's triple bond in a transition-metal-free, one-pot fashion. This review offers a guide to gauge if current methods are potentially suitable to be scaled and used in industry and pharmaceutical processes.