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PomBase in 2026: expanding knowledge, modeling connections.

Pascal Carme1,2, Kim Rutherford1, Jürg Bähler2

  • 1Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United Kingdom.

Genetics
|January 10, 2026
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Summary
This summary is machine-generated.

PomBase enhances fission yeast research with updated literature curation and new tools. New Gene Ontology - Causal Activity Modelling (GO-CAM) features support hypothesis-driven studies in Schizosaccharomyces pombe.

Keywords:
Schizosaccharomyces pombeGO-CAMMODbiocurationcausal activity modellingdatabasefission yeastknowledgebasemodel organismmodel organism database

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Area of Science:

  • * Molecular Biology
  • * Genetics
  • * Bioinformatics

Background:

  • * PomBase is the primary model organism database for the fission yeast Schizosaccharomyces pombe.
  • * Continuous updates are essential for supporting the research community effectively.

Purpose of the Study:

  • * To report recent advancements in PomBase, including literature curation and new tools.
  • * To introduce enhancements aimed at improving support for Schizosaccharomyces pombe researchers.
  • * To highlight the integration of Gene Ontology - Causal Activity Modelling (GO-CAM) for biological network curation.

Main Methods:

  • * Literature curation focusing on Schizosaccharomyces pombe research.
  • * Development and implementation of new bioinformatics tools.
  • * Curation of biological pathways and modules using Gene Ontology - Causal Activity Modelling (GO-CAM).

Main Results:

  • * Significant progress in literature curation for fission yeast.
  • * Introduction of novel tools and database enhancements.
  • * Successful application of GO-CAM to model biological pathways as causal networks.

Conclusions:

  • * PomBase continues to evolve, providing enhanced resources for fission yeast research.
  • * New GO-CAM features facilitate hypothesis-driven research by leveraging causal network models.
  • * These updates aim to better serve and advance the Schizosaccharomyces pombe research community.