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Related Experiment Video

Updated: Jan 13, 2026

Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration
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Direct Intra-Accumbens 17 Beta-Estradiol Administration Increases Voluntary Wheel Running in Ovariectomized Rats.

Dusti Shay1, Yonca Cam2, Kayla Burkle1

  • 1Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, USA.

Neuroendocrinology
|January 10, 2026
PubMed
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Estrogen (E2) delivered to the nucleus accumbens (NAc) in ovariectomized (OVX) rats increased physical activity. This finding suggests the NAc is a key brain region for estrogen-driven exercise motivation.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Exercise Physiology

Background:

  • Metabolic dysfunction and sedentary lifestyles are increasing globally.
  • Post-menopausal women face higher risks of obesity and metabolic disease due to estrogen loss.
  • The brain regions controlling the drive for physical activity are not fully understood.

Purpose of the Study:

  • To investigate the role of estrogen (E2) in the nucleus accumbens (NAc) on physical activity levels.
  • To determine if E2 replacement in the NAc can counteract exercise reduction after ovariectomy (OVX).

Main Methods:

  • Female Sprague-Dawley rats underwent OVX and NAc-targeted cannulation.
  • Daily voluntary wheel running (VWR) was monitored before and after OVX.
  • Rats received intra-accumbens microinjections of varying E2 doses (Low, Moderate, High).
Keywords:
BrainEstrogenNucleus accumbensOvariectomyVoluntary wheel running

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Main Results:

  • Intra-accumbens E2 administration significantly increased daily wheel running in OVX rats.
  • The exercise-increasing effect of E2 persisted for at least 48 hours post-injection.
  • E2 partially restored OVX-induced reductions in physical activity.

Conclusions:

  • The nucleus accumbens is a critical brain region mediating estrogen's effects on physical activity.
  • Intra-accumbens E2 delivery offers a potential strategy to combat exercise reduction associated with estrogen loss.