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Metabolomic signaling in sarcoidosis pathogenesis
Humphrey Lotana1, Tristan White1, Wonder Puryear Drake1
1Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States of America.
Current Opinion in Immunology
|January 10, 2026
Summary
Sarcoidosis, an inflammatory disease, involves abnormal immune responses. Understanding cellular metabolism and metabolomic profiles offers new insights into sarcoidosis pathogenesis and disease progression.
Area of Science:
- Immunology
- Pulmonology
- Metabolomics
Background:
- Sarcoidosis is a multisystem inflammatory disease characterized by granulomas, primarily affecting lungs and lymphatics.
- Its etiology is unknown but involves immune response to environmental triggers in susceptible individuals.
- Clinical outcomes vary, with some patients experiencing spontaneous resolution and others disease progression, potentially leading to pulmonary fibrosis and respiratory failure.
Purpose of the Study:
- To review the current understanding of metabolomics in sarcoidosis pathogenesis.
- To highlight the role of cellular metabolism in chronic lung diseases and its potential for prognosis.
- To identify key metabolites associated with sarcoidosis progression.
Main Methods:
- Literature review focusing on metabolomic studies in sarcoidosis.
- Analysis of current research on cellular metabolism in chronic lung diseases.
- Synthesis of findings on metabolomic profiles and their relation to sarcoidosis.
Main Results:
- Metabolomic profiling is a promising approach for sarcoidosis prognosis.
- Limited studies exist, but key metabolites contributing to disease progression are being identified.
- Cellular metabolism plays a significant role in the pathogenesis of chronic lung diseases like sarcoidosis.
Conclusions:
- Metabolomics offers a novel avenue for understanding sarcoidosis.
- Further research is needed to fully elucidate the role of metabolites in disease progression.
- Characterizing metabolic profiles may lead to improved diagnostic and prognostic tools for sarcoidosis.
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