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Related Experiment Video

Updated: Jan 13, 2026

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE
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White matter structure-function decoupling in juvenile myoclonic epilepsy.

Junrui Zhang1, Guangyao Liu2, Yongxuan Xu1

  • 1Institute of Brain Science and Department of Physiology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou, China; Zhejiang Philosophy and Social Science Laboratory for Research in Early Development and Childcare, Hangzhou Normal University, Hangzhou, China.

Neuroimage. Clinical
|January 10, 2026
PubMed
Summary

Juvenile myoclonic epilepsy (JME) shows early white matter structure-function decoupling, impacting motor and cognitive pathways. This finding aids in diagnosing and personalizing JME treatment strategies.

Keywords:
Juvenile myoclonic epilepsyPredictionStructure–function couplingTract-wiseWhite matter

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Area of Science:

  • Neuroscience
  • Epileptology
  • Medical Imaging

Background:

  • Juvenile myoclonic epilepsy (JME) is associated with brain alterations.
  • The link between white matter structural changes and functional disorganization in JME is not well understood.

Purpose of the Study:

  • To investigate white matter structure-function coupling (SFC) in newly diagnosed, treatment-naïve JME patients.
  • To explore the relationship between structural and functional brain changes in JME.

Main Methods:

  • Diffusion-weighted imaging (DWI) and resting-state functional MRI (fMRI) were used in 47 JME patients and 40 controls.
  • Tract-wise SFC was assessed using multivariate linear regression with microstructural metrics (FA, MD, AD, RD).
  • Support vector regression was employed to correlate findings with clinical severity.

Main Results:

  • JME patients showed widespread white matter microstructural alterations and functional hyperactivity.
  • A significant reduction in SFC was found in the left corticospinal tract and left inferior longitudinal fasciculus.
  • Multimodal models integrating structural, functional, and coupling metrics improved prediction of clinical severity.

Conclusions:

  • Early-stage JME exhibits white matter structure-function decoupling in critical motor and cognitive pathways.
  • Tract-specific SFC analysis provides a valuable tool for JME diagnosis, prognosis, and personalized treatment.