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Updated: Jan 13, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Pregnancy as a stress test: Reframing the fourth trimester as a window of intervention and postpartum precision

Athina Samara1, Asma Khalil2

  • 1FUTURE, Center for Functional Tissue Reconstruction, Department of Biomaterials, University of Oslo, Oslo, Norway; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

Med (New York, N.Y.)
|January 10, 2026
PubMed

Pregnancy triggers profound physiological changes, yet postpartum recovery remains under-recognized despite its predictive significance for lifelong health. The fourth trimester offers a critical window to detect cardiometabolic, immunological, and mental-health vulnerabilities. We propose a precision postpartum medicine framework integrating human-relevant models, longitudinal multi-omics, and AI-enabled risk stratification to transform postpartum care.

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