Quercetin rejuvenates aged adipose progenitor cells by attenuating inflammatory pathways

Area of Science:

• Aging and Metabolism
• Adipose Tissue Biology
• Cellular Senescence

Background:

• Aging leads to inguinal white adipose tissue (iWAT) mass reduction and dysfunction.
• Adipose progenitor cell (APC) aging contributes to inflammation, lipid deposition, and insulin resistance.
• Understanding APC aging mechanisms and rejuvenation strategies is crucial for metabolic health.

Purpose of the Study:

• To investigate the molecular and functional characteristics of aged APCs.
• To identify effective strategies for rejuvenating the adipogenic potential of aged APCs.
• To explore the therapeutic potential of quercetin in reversing APC aging.

Main Methods:

• Comparative analysis of APCs from young and aged mice.
• Assessment of APC frequency, inflammatory activity, and adipogenic differentiation capacity.
• Evaluation of quercetin's dose-dependent effects on APCs in vitro and in vivo.

Main Results:

• Aged mice showed decreased APC frequency, heightened inflammation, and impaired adipogenesis.
• Quercetin demonstrated concentration-dependent effects on APC vitality and function.
• Moderate quercetin doses effectively restored adipogenic differentiation in aged APCs.
• Quercetin's rejuvenating effect was linked to the suppression of pro-inflammatory pathways.

Conclusions:

• Aging significantly impairs APCs in iWAT, contributing to metabolic dysfunction.
• Quercetin, particularly at moderate doses, rejuvenates aged APCs by mitigating inflammation.
• Quercetin represents a promising therapeutic agent for age-related adipose tissue dysfunction and metabolic disorders.