Utility of renal angina index as compared to KDIGO in critically ill children at a tertiary care hospital in a low middle-income country
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View abstract on PubMed
Summary
This summary is machine-generated.The Renal Angina Index (RAI) effectively predicts severe acute kidney injury (AKI) in critically ill children. This tool shows high sensitivity and specificity, aiding early detection and management in resource-limited settings.
Area Of Science
- Pediatric critical care medicine
- Nephrology
- Diagnostic accuracy studies
Background
- Acute kidney injury (AKI) is a significant concern in critically ill children.
- Early prediction of severe AKI is crucial for timely intervention and improved outcomes.
- Conventional biomarkers for AKI may be limited in resource-constrained settings.
Purpose Of The Study
- To assess the diagnostic accuracy of the Renal Angina Index (RAI) for predicting severe AKI in critically ill children.
- To compare RAI's performance against Kidney Disease Improving Global Outcomes (KDIGO) criteria.
- To evaluate RAI's utility in a low-middle-income country tertiary care setting.
Main Methods
- A cross-sectional study involving 278 critically ill children (1 month to 18 years) admitted to the Pediatric Intensive Care Unit (PICU).
- RAI was calculated within 24 hours of PICU admission.
- Severe AKI was defined by KDIGO stage 2 or 3; outcomes included need for renal replacement therapy (RRT), PICU length of stay, and mortality.
Main Results
- RAI identified 53.2% of patients as positive for severe AKI.
- RAI demonstrated high diagnostic accuracy with 82% sensitivity, 87% specificity, and an AUC of 0.90.
- RAI-positive patients had significantly increased requirements for diuretics, RRT, longer PICU stays, and higher mortality.
Conclusions
- The Renal Angina Index is a sensitive and specific tool for early identification of severe AKI in critically ill pediatric patients.
- RAI can significantly enhance AKI detection and management, particularly in resource-limited settings.
- Implementation of RAI may lead to improved clinical outcomes for pediatric AKI.
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