Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 30, 2026

Bringing the Visible Universe into Focus with Robo-AO
10:35

Bringing the Visible Universe into Focus with Robo-AO

Published on: February 12, 2013

20.0K

Rapid wavefront shaping using an optical gradient acquisition.

Sagi Monin1, Marina Alterman1, Anat Levin2

  • 1Department of Electrical and Computer Engineering, Technion, Haifa, Israel.

Nature Communications
|January 10, 2026
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single pixel imaging at megahertz switching rates via cyclic Hadamard masks.

Nature communications·2021
Same journal

Demonstration of a quantum C-NOT gate in a time-multiplexed fully reconfigurable photonic processor.

Nature communications·2026
Same journal

Nonlinear quantum light source with van der Waals ferroelectric NbOX<sub>2</sub> (X = Br, I).

Nature communications·2026
Same journal

Antagonistic histone H2A variants and autonomous heterochromatin formation shape epigenomic patterns in Arabidopsis.

Nature communications·2026
Same journal

The long tail of nitrate pollution in groundwater challenges governance of global water quality.

Nature communications·2026
Same journal

Select microbial metabolites promote tau aggregation in a murine tauopathy model.

Nature communications·2026
Same journal

Warming climate has lengthened global intense tropical cyclone seasons.

Nature communications·2026
See all related articles

This study introduces a rapid wavefront shaping system using gradient descent for faster deep tissue imaging. It overcomes limitations of slow coordinate descent by enabling simultaneous updates of all modulation parameters.

Area of Science:

  • Biomedical Optics
  • Microscopy
  • Optical Engineering

Background:

  • Deep tissue imaging is hindered by scattering aberrations.
  • Current wavefront shaping methods (coordinate descent) are slow and scale poorly with parameters.
  • Estimating optimal modulation correction is difficult due to unknown tissue structures.

Purpose of the Study:

  • To develop a rapid wavefront shaping system for efficient deep tissue imaging.
  • To replace slow coordinate descent with a faster gradient descent optimization.
  • To enable fast, high-resolution wavefront correction independent of parameter count.

Main Methods:

  • Implemented a gradient descent optimization for wavefront shaping.
  • Acquired a gradient vector for simultaneous update of all modulation parameters.

More Related Videos

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping
09:43

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping

Published on: March 20, 2017

10.3K
Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator
08:39

Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator

Published on: January 28, 2019

10.3K

Related Experiment Videos

Last Updated: May 30, 2026

Bringing the Visible Universe into Focus with Robo-AO
10:35

Bringing the Visible Universe into Focus with Robo-AO

Published on: February 12, 2013

20.0K
Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping
09:43

Transmission of Multiple Signals through an Optical Fiber Using Wavefront Shaping

Published on: March 20, 2017

10.3K
Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator
08:39

Shaping the Amplitude and Phase of Laser Beams by Using a Phase-only Spatial Light Modulator

Published on: January 28, 2019

10.3K
  • Utilized a non-invasive, guide-star-free score function and analytically derived its gradient.

    • Main Results:

    • Demonstrated a rapid wavefront shaping system overcoming coordinate descent limitations.
    • Achieved wavefront correction with complexity independent of parameter count.
    • Successfully corrected aberrations in a coherent confocal microscope.

    Conclusions:

    • The novel gradient descent approach enables faster and more efficient wavefront shaping.
    • This system significantly improves deep tissue imaging capabilities.
    • The method is effective for aberration correction in advanced microscopy techniques.