Association between maternal SARS-CoV-2 infection & clinical outcomes in infants: A multicentric retrospective cohort study in India
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View abstract on PubMed
Summary
This summary is machine-generated.Maternal COVID-19 infection increases stillbirth risk and newborn intensive care unit admissions. Infant development milestones were unaffected in low- and middle-income countries.
Area Of Science
- Perinatal health
- Infectious disease epidemiology
- Child development
Background
- Limited data exists on COVID-19's impact on perinatal outcomes and infant development in low- and middle-income countries.
- Understanding these effects is crucial for maternal and child health strategies.
Purpose Of The Study
- To investigate the impact of maternal COVID-19 infection during pregnancy on neonatal outcomes.
- To assess the effect on infant development up to one year of age.
Main Methods
- Retrospective cohort study comparing pregnant women with and without COVID-19 exposure.
- Data collected via hospital records and maternal interviews.
- Propensity score matching used to minimize selection bias.
Main Results
- Maternal SARS-CoV-2 infection was linked to increased stillbirth risk (aOR 2.63) and higher admission rates to the special newborn care unit (SNCU) (aOR 2.57).
- Infants born to mothers with COVID-19 had a significantly higher risk of illness (RR 4.23).
- Developmental milestone attainment by age one was similar between exposed and unexposed infant cohorts.
Conclusions
- COVID-19 in pregnancy elevates the risk of stillbirth and necessitates increased SNCU admissions for newborns.
- No significant differences were observed in the age of developmental milestone achievement between infants of mothers with and without COVID-19.
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