Related Experiment Video
Updated: Jan 13, 2026
Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
Published on: September 16, 2022
Hypothyroidism in adult spinal deformity
Tiffany Chu1, Munira Ali1, Vikram Murugan1
1Department of Neurosurgery, Creighton University School of Medicine, 7500 Mercy Road, Omaha, NE, 68124, USA.
Hypothyroidism is more common in adults with spinal deformity. This condition, along with higher TSH levels and female gender, is linked to increased Cobb angle severity in adult degenerative scoliosis.
Area of Science:
- Endocrinology
- Orthopedics
- Spine Surgery
Background:
- Hypothyroidism is increasingly recognized in patients with degenerative spine conditions.
- Adult spinal deformity (ASD) presents a growing clinical challenge.
Purpose of the Study:
- To investigate the prevalence of hypothyroidism in patients diagnosed with adult spinal deformity.
- To explore potential correlations between the Cobb angle, a measure of spinal curvature, and thyroid dysfunction markers in this patient group.
Main Methods:
- A multi-center retrospective study reviewed 834 adult patients (≥60 years) with spinal deformity.
- Data collected included demographics, hypothyroidism diagnosis, thyroid panel results (TSH, free T4), Cobb angle, and bone mineral density.
Main Results:
- Hypothyroidism was diagnosed in 33.3% of ASD patients.
- Hypothyroidism, elevated TSH, and female gender were significantly associated with a larger Cobb angle in adult degenerative scoliosis.
- No association was found between hypothyroidism, TSH, free T4, and bone mineral density.
Conclusions:
- The prevalence of hypothyroidism is elevated in patients with adult spinal deformity.
- Thyroid dysfunction markers (hypothyroidism, TSH) and female gender correlate with increased spinal curvature severity (Cobb angle).
- Further research is warranted to elucidate the complex relationship between hypothyroidism and spinal deformity.
More Related Videos
04:19Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
Published on: November 8, 2024
07:44Evaluation of Patients' Posture and Gait Profile After Lumbar Fusion Surgery by Video Rasterstereography and Treadmill Gait Analysis
Published on: March 23, 2019
Related Concept Videos
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:16Vertebral Column: Regions and Curvature
Regions of the Vertebral Column
In an adult, the spine is subdivided into five regions: the cervical, the thoracic, the lumbar, the sacral, and the coccygeal region. The spine initially develops as a series of 33 vertebrae; after 20 years of age, the nine bones in the sacral region, five sacral, and four coccygeal bones fuse to form...
01:28Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
01:09Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...