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Updated: Jan 13, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
Five Pathogenetic Classifications for Alloimmune Hemolytic Disease of the Fetus And Newborn
Hitoshi Ohto1, Kenneth E Nollet1, Jill R Storry2
1Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University School of Medicine, Fukushima, Japan; Radiation Medical Science Centre for the Fukushima Health Management Survey, Fukushima Medical University, Fukushima, Japan.
Abstract:
Maternal alloantibody-induced hemolytic disease of the fetus and newborn (HDFN) remains a significant concern worldwide. Alloimmune HDFN can be pathogenetically named by the specific alloantibodies involved. Moreover, four mechanistic pathway types are generally recognized in clinical practice: classical or extravascular hemolysis; immune-pressure-escaped, also known as antibody-mediated antigen-modulation; apoptotic or dysplastic; and failed transaction. Another proposed pathway is worthy of discussion: lactation-mediated. Management strategies for alloimmune HDFN should take account of these underlying mechanisms.
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