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Target validation of natural compounds: Perillaldehyde case study.

Andrea Blesio1, Carmine Giorgio2, Stefano Sala2

  • 1University of Parma; Food and Drug department, Viale delle Scienze 27/A, 43124 Parma, Italy; University of Parma, Department of Medicine and Surgery, Via Volturno 39, 43126 Parma, Italy.

International Immunopharmacology
|January 11, 2026
PubMed
Summary

Perillaldehyde (PAE) was thought to target the EphA2 receptor by blocking ephrin-A1 binding. However, this study found PAE does not inhibit this interaction, highlighting challenges in natural compound drug discovery.

Keywords:
Drug discoveryNatural compoundsPAINSPPI-inhibitorsValidation

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