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Lung computed tomography (CT) imaging findings of chronic obstructive pulmonary disease patients with impaired sleep
1Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Research Unit of Respiratory Disease, Central South University, Changsha, Hunan 410011, China; Clinical Medical Research Center for Pulmonary and Critical Care Medicine in Hunan Province, 410011, China; Diagnosis and Treatment Center of Respiratory Disease, Central South University, Changsha, Hunan 410011, China.
Aim:
To investigate the computed tomography (CT) imaging characteristics (including diaphragm thickness [DT], pulmonary artery to aorta ratio [dPA/A], and airway indices) associated with impaired sleep quality in chronic obstructive pulmonary disease (COPD) patients.
Materials And Methods:
This cross-sectional study enrolled 190 COPD patients (December 2021-September 2024). Baseline data included demographics, COPD Assessment Test (CAT) scores, pulmonary function, exacerbation history, and CT parameters. Impaired sleep quality was defined as Pittsburgh Sleep Quality Index (PSQI) score ≥5, grouping patients accordingly.
Results:
Patients (mean age 64.8 years; 93.1% male) included 56% with impaired sleep quality (linked to higher CAT scores and lower FEV1/FVC). The impaired sleep group had smaller airway lumen area (LA), mean inner/outer diameters (mID/mOD), and DT; plus higher wall area percentage (WA%) and dPA/A. DT, WA%, and dPA/A were independent risk factors for impaired sleep; dPA/A had the highest ROC AUC (0.688), followed by CAT (0.667), DT (0.632), and WA% (0.602).
Conclusion:
Impaired sleep quality in COPD may relate to airway narrowing, airway wall thickening, reduced lumen diameter, and enlarged dPA/A.
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