Chronic Urticaria Part I: Clinical overview and molecular basis

Area of Science:

• Dermatology
• Immunology
• Pathophysiology

Background:

• Chronic urticaria (CU) is a mast cell-driven skin disorder.
• Characterized by recurrent wheals and/or angioedema for over six weeks.
• Requires updated knowledge for effective diagnosis and management.

Purpose of the Study:

• To provide an in-depth review of Chronic Urticaria for dermatologists.
• To empower dermatologists with knowledge for confident diagnosis and management.
• To integrate recent advances in CU research.

Main Methods:

• Review of epidemiology, classification, pathogenesis, clinical features, diagnosis, and comorbidities.
• Integration of advances in disease endotyping and mast cell biology.
• Outline of pathophysiologic mechanisms, prognostic markers, and clinical assessment tools.

Main Results:

• Provides a comprehensive overview of CU's current understanding.
• Highlights recent advances in mast cell biology and immune cell crosstalk.
• Equips dermatologists with knowledge of diagnostic and prognostic markers.

Conclusions:

• This review enhances dermatologists' ability to diagnose and manage CU.
• Understanding pathophysiologic mechanisms is key to improving patient care.
• Prepares clinicians for emerging therapeutic options discussed in Part II.