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Radiation Therapy Target Objectives for Tonsillar Cancer Treated With Unilateral Radiation Therapy-A Replanning Study
Glen Osbourne1, Aimee Devlin2, Nadia Walsh1
1Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
International Journal of Radiation Oncology, Biology, Physics
|January 11, 2026
Summary
Re-optimizing unilateral radiotherapy (URT) plans for tonsil cancer significantly spares organs at risk. New guidelines maximize contralateral and midline organ sparing while maintaining target coverage for better patient outcomes.
Area of Science:
- Radiation Oncology
- Medical Physics
Background:
- Unilateral radiotherapy (URT) is effective for lateralized tonsil cancer.
- Current URT planning lacks guidelines, leading to suboptimal sparing of midline and contralateral organs at risk (OARs).
Purpose of the Study:
- To re-optimize URT plans to maximize sparing of midline and contralateral OARs.
- To provide dosimetric guidelines for URT planning.
Main Methods:
- Re-optimized URT treatment plans using Eclipse V16.01.
- Contoured OARs according to international consensus guidelines.
- Aimed for maximal OAR sparing while meeting XXXX and NRG protocol target coverage criteria.
Main Results:
- Achieved target volume coverage for both XXXX and NRG protocols.
- Demonstrated significant dose reductions to pharyngeal constrictors, contralateral submandibular gland, and larynx.
- Showed dose reductions to contralateral parotid gland and oral cavity, with no increase in mandible dose.
Conclusions:
- Re-optimized URT plans provide achievable OAR sparing.
- Offers planning guidelines for dosimetrists and radiation oncologists for URT delivery.
