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Author Spotlight: Optimizing Scorpion Venom Extraction for Antivenom Production
Published on: October 6, 2023
Influence of the ABO system on the hemolytic activity of medically relevant Loxosceles venoms in Brazil
Martina Beltramino1, Isabella Gizzi Jiacomini1, Bianca Prado-Costa1
1Universidade Federal do Paraná, Departamento de Patologia Básica, Laboratório de Imunoquímica, Curitiba, PR, Brazil.
Abstract:
Envenomation by Loxosceles spiders is an important public health issue, frequently associated with hemolysis. Although the ABO blood group system influences various diseases, its role in loxoscelism is poorly understood. This study evaluated the effect of ABO types on hemolysis induced by L. intermedia, L. gaucho, and L. laeta venoms, with and without complement. Blood type B erythrocytes showed reduced susceptibility to direct hemolysis, suggesting a potential protective effect and offering new insights for improving loxoscelism management.
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