Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

14.0K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
14.0K
Improving Translational Accuracy02:07

Improving Translational Accuracy

3.5K
3.5K
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

495
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
495
Reconstruction of Signal using Interpolation01:10

Reconstruction of Signal using Interpolation

679
Signal processing techniques are essential for accurately converting continuous signals to digital formats and vice versa. When a continuous signal is sampled with a period T, the resulting sampled signal exhibits replicas of the original spectrum in the frequency domain, spaced at intervals equal to the sampling frequency. To handle this sampled signal, a zero-order hold method can be applied, which creates a piecewise constant signal by retaining each sample's value until the next...
679
Extraction: Partition and Distribution Coefficients01:14

Extraction: Partition and Distribution Coefficients

4.6K
The distribution law or Nernst's distribution law is the law that governs the distribution of a solute between two immiscible solvents. This law, also known as the partition law, states that if a solute is added to the mixture of two immiscible solvents at a constant temperature, the solute is distributed between the two solvents in such a way that the ratio of solute concentrations in the solvents remains constant at equilibrium.
For extracting a solute from an aqueous phase into an...
4.6K
Methods of Obtaining Topography01:25

Methods of Obtaining Topography

275
Topography involves measuring and mapping land elevations, natural features, and artificial structures to create accurate representations of the terrain. Topographic surveying relies on traditional and modern methods, each with distinct advantages and limitations.Traditional Surveying Methods:Transit stadia surveys and plane table surveys were widely used traditional surveying methods. These techniques relied on instruments like theodolites and stadia rods for measuring distances and angles,...
275

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laser-Emitting Droplet Assay for Enzymatic Evaluation Applications.

ACS nano·2026
Same author

KLF4/FOXF1 axis alleviates silicosis fibrosis by modulating fibroblast behavior and extracellular matrix remodeling.

Journal of environmental sciences (China)·2026
Same author

Interphasial Catalytic Anion Reduction for Stable Anode-Free Sodium-Metal Batteries.

Journal of the American Chemical Society·2026
Same author

Modified chitosan micelles improving physical stability, sustained release, and antibacterial activity of fir essential oil: performance optimization and mechanistic insights.

Food chemistry·2026
Same author

Impact of Preoperative Frailty on Postoperative Functional Recovery and Quality of Life in Elderly Patients With Gastrointestinal Tumors.

Annali italiani di chirurgia·2026
Same author

Robust strong coupling of single quantum emitters with plasmonic nanocavity on one-dimensional photonic crystal substrate.

Fundamental research·2026
Same journal

Targeted Delivery of Indole-3-Pyruvic Acid Suppresses Macrophage Ferroptosis to Enhance CD8<sup>+</sup> T Cell-Mediated Immunotherapy Response in Bladder Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Pathological Copper Overload Reprograms SOD1 Activation via COMMD1 to Promote Senescence and Fibrosis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Bending-Resistant Intimate 3D Graphene-Metal Heterojunctions for Highly Sensitive and Robust Flexible Sensors.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

A Pathology-Instructed Theranostic Platform with Mechanoadaptive and ROS-Powered Nanobreathing Functions for Precision Myocardial Repair.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

Targeting p21-High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same journal

A Ceramic Network for Hybrid Solid Electrolyte Lithium Metal Batteries.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
See all related articles

Related Experiment Video

Updated: Jan 13, 2026

Mining Spatial Transcriptomics Datasets using DeepSpaceDB
10:16

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Published on: September 5, 2025

632

Reconstructing Coherent Functional Landscape From Multi-Modal Multi-Slice Spatial Transcriptomics by a Variational

Zedong Wang1, Bowen Fu1, Chuanchao Zhang1

  • 1Key Laboratory of Systems Health Science of Zhejiang Province School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 12, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces stVGP, a novel framework for 3D spatial transcriptomics analysis. It enables accurate 3D reconstruction and gene expression interpolation from 2D tissue sections, advancing biological insights.

Keywords:
multi‐modalspatial transcriptomicsvariational spatiotemporal gaussian process

More Related Videos

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.1K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.2K

Related Experiment Videos

Last Updated: Jan 13, 2026

Mining Spatial Transcriptomics Datasets using DeepSpaceDB
10:16

Mining Spatial Transcriptomics Datasets using DeepSpaceDB

Published on: September 5, 2025

632
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.1K
Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
03:37

Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers

Published on: March 1, 2024

1.2K

Area of Science:

  • Genomics
  • Computational Biology
  • Bioinformatics

Background:

  • Spatial transcriptomics (ST) technologies offer insights into tissue organization.
  • Current ST analysis is limited to 2D, hindering full 3D understanding.
  • A need exists for methods to integrate and reconstruct 3D spatial data.

Purpose of the Study:

  • To introduce stVGP, a variational spatial Gaussian process framework.
  • To enable alignment, integration, and 3D reconstruction of spatial transcriptomic data.
  • To facilitate 3D spatial domain identification and gene expression interpolation.

Main Methods:

  • Developed stVGP, integrating spatial Gaussian processes and hierarchical transformers.
  • Applied stVGP to multi-modal, multi-slice ST datasets.
  • Enabled virtual slice generation for continuous 3D reconstruction.

Main Results:

  • stVGP achieved superior performance in cross-slice alignment and domain detection.
  • The framework accurately predicted gene expression in unsampled regions.
  • Enabled high-fidelity virtual transcriptomic reconstruction from histology images.

Conclusions:

  • stVGP provides a unified framework for 3D spatial landscape modeling.
  • It bridges the gap between 2D ST data and continuous 3D biological understanding.
  • Facilitates deeper insights into complex tissues and developmental systems.