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Isopropyl Alcohol-Induced Peripheral Neuropathy After Transdermal Exposure: A Case Report.

Jack Shapiro1, Thomas Cranmer2, Emma Formaro3

  • 1Department of Medicine, Northwestern Medicine Feinberg School of Medicine, Chicago, IL, USA.

Journal of Pharmacy Practice
|January 12, 2026
PubMed
Summary
This summary is machine-generated.

Transdermal isopropyl alcohol (IPA) exposure can cause peripheral neuropathy, a rare condition. Stopping topical IPA use led to full recovery in an 80-year-old man, highlighting the importance of considering this exposure route.

Keywords:
isopropanolisopropyl alcoholneuropathytoxicologytransdermal

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Area of Science:

  • Neurology
  • Toxicology

Background:

  • Peripheral neuropathy has many causes, including toxins.
  • Isopropyl alcohol (IPA) toxicity is known from ingestion, but skin absorption causing neuropathy is uncommon.
  • IPA metabolizes to acetone, potentially neurotoxic, and chronic skin exposure may damage nerves.

Purpose of the Study:

  • To report a rare case of peripheral neuropathy caused by transdermal isopropyl alcohol exposure.
  • To highlight the neurotoxic potential of topical IPA application.

Main Methods:

  • A case report of an 80-year-old male patient.
  • Clinical assessment and differential diagnosis to rule out other causes of neuropathy.
  • Monitoring patient's response to cessation of topical IPA application.

Main Results:

  • The patient developed numbness in his left lower extremity after 3 months of daily topical IPA application.
  • Other potential causes for neuropathy were excluded.
  • Complete resolution of symptoms occurred within 3 weeks of discontinuing IPA use.

Conclusions:

  • Topical isopropyl alcohol application can lead to peripheral neuropathy.
  • This case underscores the importance of considering transdermal IPA exposure in patients with unexplained neuropathy.
  • Discontinuation of IPA is an effective treatment for this type of neuropathy.