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Prognostic Value Of Baseline 18f-fdg Pet/ct Metabolic Parameters In Post-transplant Lymphoproliferative Disorder After Pediatric Liver Transplantation.

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Prognostic Value Of Baseline 18f-fdg Pet/ct Metabolic Parameters In Post-transplant Lymphoproliferative Disorder After Pediatric Liver Transplantation.

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Prognostic value of baseline ¹⁸F-FDG PET/CT metabolic parameters in post-transplant lymphoproliferative disorder

Chaoran Wang^1,2, Keyu Zhang¹, Guanyun Wang¹

¹Nuclear Medicine Department, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Quantitative Imaging in Medicine and Surgery

|January 12, 2026

View abstract on PubMed

Summary

This summary is machine-generated.

Keywords:

Post-transplant lymphoproliferative disorder (PTLD)fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)liver transplant pediatric prognosis

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Baseline fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT scans can predict outcomes for pediatric liver transplant patients with post-transplant lymphoproliferative disorder (PTLD). Total lesion glycolysis (tTLG) is a key independent predictor of progression-free survival.

Area of Science:

Nuclear Medicine
Oncology
Transplantation Medicine

Background:

Post-transplant lymphoproliferative disorder (PTLD) is a significant complication following pediatric liver transplantation (pLT).
Limited studies have assessed the prognostic value of pretreatment fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) in PTLD patients post-pLT.

Purpose of the Study:

To evaluate the prognostic significance of baseline 18F-FDG PET/CT imaging in patients diagnosed with PTLD after pLT.
To identify metabolic parameters from 18F-FDG PET/CT that predict patient outcomes.

Main Methods:

Retrospective analysis of 42 patients with pathologically diagnosed PTLD post-pLT who underwent baseline 18F-FDG PET/CT before treatment.
Measurement of metabolic parameters including SUVmax, SUVpeak, SUVavg, MTV, TLG, tMTV, and tTLG.

Assessment of prognostic significance using Cox proportional hazards regression and Kaplan-Meier analysis for progression-free survival (PFS).

Main Results:

During a median follow-up of 638 days, 61.9% of patients experienced PFS events (recurrence, progression, or mortality).
Univariate analysis identified serum tacrolimus level, morphology, SUVmax, TLG, tMTV, and tTLG as significant PFS predictors.
Multivariate analysis revealed total TLG (tTLG) as a significant independent predictor of PFS (HR=4.942, P<0.001).

Conclusions:

Baseline 18F-FDG PET/CT metabolic parameters are valuable for predicting the prognosis of PTLD patients after pLT.
Total lesion glycolysis (tTLG) emerges as a critical independent prognostic factor for progression-free survival in this cohort.