Exploring the association between the ZJU index and overactive bladder: a cross-sectional study based on NHANES...

Area of Science:

• Urology
• Metabolic Health
• Public Health

Background:

• Overactive bladder (OAB) affects 16% of the global population and is linked to metabolic factors.
• The ZJU index, integrating BMI, FBG, TG, and ALT/AST ratio, correlates with lipid metabolism.
• The relationship between the ZJU index and OAB has not been previously studied.

Purpose of the Study:

• To investigate the association between the ZJU index and OAB prevalence.
• To evaluate the ZJU index as a potential predictive tool for OAB.
• To inform early intervention strategies for OAB.

Main Methods:

• Cross-sectional analysis of NHANES data (2011-2018) including 15,873 participants.
• ZJU index categorized into quartiles; OAB association examined via multivariate logistic regression.
• Restricted cubic splines and subgroup analyses performed to explore nonlinear relationships.

Main Results:

• A nonlinear association was found between the ZJU index and OAB prevalence (OR=1.79, P<0.001).
• OAB risk increased with higher ZJU index levels.
• The association was significantly stronger in women (OR=1.03, P<0.001) than in men.

Conclusions:

• The ZJU index is significantly associated with increased OAB risk, especially in women.
• This finding suggests the ZJU index may serve as a valuable indicator for OAB risk.
• Further research is warranted to elucidate the underlying mechanisms and confirm these results.