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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Related Experiment Video

Updated: Jan 13, 2026

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma
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Primary Intracranial Alveolar Soft Part Sarcoma: Systematic Review.

Haseeb Mehmood Qadri1, Hasan Saeed2, Muhammad Awais Ahmad3

  • 1Haseeb Mehmood Qadri, MBBS. Punjab Institute of Neurosciences, Lahore, Pakistan.

Pakistan Journal of Medical Sciences
|January 12, 2026
PubMed
Summary

Primary intracranial alveolar soft part sarcoma is rare. Surgical resection is the main treatment, with Transcription Factor E3 aiding diagnosis. Long-term monitoring is crucial for this slow-growing brain tumor.

Keywords:
Alveolar soft partBrain neoplasmsNeoplasmsPakistanSarcomaUnknown primary

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Area of Science:

  • Neuro-oncology
  • Rare tumors
  • Surgical pathology

Background:

  • Alveolar soft part sarcoma (ASPS) is a rare malignancy with unknown origins.
  • Primary intracranial ASPS is exceptionally uncommon.
  • Understanding its clinical course and management is vital.

Purpose of the Study:

  • To systematically review primary intracranial alveolar soft part sarcoma.
  • To analyze clinical manifestations, progression, and treatment strategies.

Main Methods:

  • Systematic review of PubMed, Google Scholar, and ScienceDirect (2000-2024).
  • Included 18 cases from reports and series.
  • Data extracted on presentation, imaging, pathology, and outcomes.

Main Results:

  • Predominantly affected females (61.1%) with a mean age of 23.3 years.
  • Common symptoms included headache (50%) and papilledema (33.3%).
  • Frontal lobe was the most frequent site (33.3%); gross total resection achieved in 77.8%.

Conclusions:

  • Surgical resection is the primary treatment modality.
  • Transcription Factor E3 immunopositivity supports diagnosis.
  • Long-term surveillance is necessary due to the indolent nature of the tumor.