Related Experiment Video
Updated: Jan 13, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
Variable Priority for Unsupervised Variable Selection
Lili Zhou1, Min Lu1, Hemant Ishwaran1
1Division of Biostatistics, Miller School of Medicine, University of Miami.
Abstract:
In unsupervised settings where labeled data is unavailable, identifying informative features is both challenging and essential. Although numerous methods for unsupervised feature selection have been proposed, significant opportunities for improvement remain. This paper introduces a new method that extends the supervised Variable Priority (VarPro) framework to the unsupervised domain. The central idea is to recast feature selection as a collection of localized two-class classification problems, where class labels are defined by membership in regions derived using decision tree rules and their corresponding releases. This transformation introduces a form of implicit supervision without requiring outcome labels and is combined with lasso-based regression to encourage sparsity and mitigate noise in high-dimensional settings. Extensive experiments on synthetic benchmarks demonstrate consistent improvements over existing methods across a range of latent, correlated, and clustered scenarios. Real-world validation in biological and image data further confirms the method's effectiveness, including recovery of known cancer-associated genes and improved clustering in lung cancer subtyping.
Related Concept Videos
Multi-input and Multi-variable systems
In the absence of...
Variability: Analysis
The range is a simple measure of variability, indicating the difference between the highest and...
Randomized Experiments
Simple randomization
Simple...
Quantifying and Rejecting Outliers: The Grubbs Test
Random Variables
Uppercase letters such as X or Y denote a random variable. Lowercase letters like x or y denote the value of a random variable. If X is a random variable, then X is written in words, and x is given as a number.
For example, let X = the...
Decision Making: P-value Method
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can...

