The Impact of Donor Hematological Parameters on Early Donor Complications: A Multicenter Donor Research Team Project

Recommendations regarding hematopoietic stem cell donor medical suitability are generally expert opinions and include legal regulations. With this study, we aimed to determine the frequency of hematological abnormalities and the effect of these abnormalities on early complications in related hematopoietic stem cell donors. Adult donors of allogeneic related peripheral blood hematopoietic stem cell transplantations performed between 01.Jan.2011 and 01.Jan.2021 were included in this multicenter study retrospectively. There were 318 donors. Baseline anemia (7.5%), was the most frequently observed hematological abnormality and found to be an independent risk factor for the development of any degree of anemia on the day of apheresis (p = 0.003, OR 18.6, 95% CI 2.6-131.5). Clinical complications and other laboratory complications were not significantly related to baseline hematological variables in the multivariate analysis. Although baseline hematological abnormalities are common in donors, their impact on early donor complications seems controversial.